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Dosage should be increased more slowly and with regular monitoring for fluid and nutritional intake, dehydration, somnolence, and other adverse reactions.
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In some cases, hepatic dysfunction has progressed despite discontinuance of the drug.
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Divalproex sodium delayed-release tablet is a valproate and is indicated for the treatment of the manic episodes associated with bipolar disorder.
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Breast-feeding by mothers taking Depakote ER should be safe for healthy, full-term newborns.
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Since divalproex sodium products may produce CNS depression, especially when combined with another CNS depressant (e.
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Asberg Depression Rating Scale and the Young Mania Rating Scale, respectively.
Depakote, Depakote ER, and Depakote Sprinkle Capsules are contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and in children under two years of age who are clinically suspected of having a mitochondrial disorder.
One twelve-month study was conducted to evaluate the safety of divalproex sodium in the indication of partial seizures (169 patients aged 3 to 10 years).
Mood-stabilizing medications were adjusted clinically to target the therapeutic range for each drug.
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Follow your doctor's instructions about taking divalproex sodium while you are pregnant.
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LIVER FUNCTION TESTS SHOULD BE PERFORMED PRIOR TO THERAPY AND AT FREQUENT INTERVALS THEREAFTER, ESPECIALLY DURING THE FIRST SIX MONTHS.
This is a result of reduced clearance (perhaps due to delay in development of glucuronosyltransferase and other enzyme systems involved in valproate elimination) as well as increased volume of distribution (in part due to decreased plasma protein binding).
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To avoid unwanted side effects, the doctor will prescribe a low dose to start and increase it gradually until the seizures are controlled, unless side effects get too bad first.
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Do not drive a car or operate dangerous machinery until you know how divalproex sodium extended-release tablets affect you.
It can be swallowed whole or the capsules may be opened carefully and the contents sprinkled on about one teaspoonful of applesauce or pudding.
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Tolerability was assessed using the UKU Side Effect Rating Scale for adverse effects.
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Divalproex sodium delayed-release capsules provide the medicine that your healthcare provider has prescribed.
During the outpatient phase, participants were instructed to abstain from illicit drugs (excluding marijuana, for which no instructions were given).
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In the past, emphasis was placed solely on the treatment of acute episodes of bipolar disorder; recently, the importance of episode prevention and of minimisation of iatrogenicity has been recognised.
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The challenge among physicians is not only when to start a daily preventive agent but which preventive agent to choose.
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The adverse event profile of long-term divalproex therapy for epilepsy is well established, but little is known about the tolerability or safety of divalproex in long-term migraine prophylaxis.
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient.
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Although controlled release products are generally preferred, in some patients they interrupt sleep to a greater extent than immediate release products.
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Does not appear to inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, or CYP3A4 in vitro; pharmacokinetic interaction with substrates of these isoenzymes unlikely.
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The following adverse events occurred in at least 5% of Divalproex Sodium Delayed-Release Tablets-treated patients and at an equal or greater incidence for placebo than for Divalproex Sodium Delayed-Release Tablets: flu syndrome and pharyngitis.
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Depakote (divalproex sodium): "Noticed that depakote improved stability of mood and reduced depression.
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