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Careful assessment of the risk of infection, adverse effects of the antifungal agent, potential efficacy of the regimen, and impact of prophylaxis on outcome must be considered in determining whether prophylaxis should be administered to all patients or directed towards a subset of patients, the choice of antifungal agent, and its mode of administration.
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Treatment of infections requiring multiple dosing should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided.
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Of course if an antibiotic taken by injection is meant to clear an infection it may also wipe out intestinal bacteria and may be a problem.
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First of a new class of antifungal drugs (glucan synthesis inhibitors).
Some infections will resolve without antifungal treatment, but some physicians choose to treat all symptomatic patients.
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Fluconazole injection is also sometimes used to treat serious fungal infections that begin in the lungs and can spread through the body and fungal infections of the eye, prostate (a male reproductive organ), skin and nails.
However, the administration of cimetidine 600 mg to 900 mg intravenously over a four-hour period (from one hour before to 3 hours after a single oral dose of fluconazole 200 mg) did not affect the bioavailability or pharmacokinetics of fluconazole in 24 healthy male volunteers.
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Halperin, Associate Professor of Medicine at Harvard Medical School in the Laboratory for Membrane Transport, includes the anti-cancer applications to a large number of new chemical entities (NCEs) which are related to the anti-fungal agent, clotrimazole, and the anti-cancer applications of clotrimazole itself.
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Fluconazole increases the AUC of saquinavir by approximately 50%, Cmax by approximately 55%, and decreases clearance of saquinavir by approximately 50% due to inhibition of saquinavir's hepatic metabolism by CYP3A4 and inhibition of P-glycoprotein.
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