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Pyrin, the protein encoded by MEFV, has been shown to interact with cryopyrin, the protein encoded by NLRP3, which is an important active member of the inflammasome.
What is the recommended management of this mass?
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Therapy with corticosteroids resulted in complete remission in 54%, partial remission in 30%, and no response in 16%.
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Although pulse cyclophosphamide may offer less cumulative toxicity, additional studies are needed before this method is accepted for treatment of frequently relapsing or glucocorticoid-resistant minimal change disease.
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