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However, this effect is temporary and after a median of 18-24 months, there is disease progression, heralded by rising serum prostate-specific antigen (PSA), increasing tumor size, new metastatic spread and disease-related symptoms.
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In another embodiment of the procedure according to the invention, in said step a) the reagents are used without solvent, either in the absence of base or with catalysis by 3% of MeONa (used as a 30% solution).
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Non-physiological gynaecomastia develops with disorders or drugs associated with low testosterone levels, high testosterone conversion to oestrogen, high oestrogen levels, and high sex hormone binding globulin levels resulting in low free testosterone (see boxes).
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Many centers offer multidisciplinary clinics where the patient can consult with urologists, and with radiation and medical oncologists at one location.
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