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However, this effect is temporary and after a median of 18-24 months, there is disease progression, heralded by rising serum prostate-specific antigen (PSA), increasing tumor size, new metastatic spread and disease-related symptoms.

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Non-physiological gynaecomastia develops with disorders or drugs associated with low testosterone levels, high testosterone conversion to oestrogen, high oestrogen levels, and high sex hormone binding globulin levels resulting in low free testosterone (see boxes).

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