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This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
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Preferably, the method comprises: administering the CNS active agent to a patient; and administering at least two vagal neuromodulators to the patient in an amount sufficient to reduce a side-effect of the CNS active agent.
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The invention is further directed to a method of reducing a side-effect of a CNS active agent.
Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges.
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Examples of such ionic liquid compositions include, but are not limited to, compositions where the cation is an antibacterial agent such as benzalkonium, didecyldimethylammonium, or N-hexadecylpyridinium, and the anion is Fast Green FCF, an FDA approved color additive that provides a sea green hue and is used in products such as beverages, puddings, ice cream, sherbet, cherries, confections, baked goods, and dairy products.
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In other words, according to the disclosed methods, ionic liquid compositions that contain varying effective amounts (or doses) of active substances can be prepared by varying the ratios of ions in the composition, as long as the total amount of cations is balanced by the total amount of anions.
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The term “ketone” as used herein is represented by the formula A 1C(O)A 2, where A 1 and A 2 can be, independently, an alkyl, halogenated alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl group described above.
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The term “release controlling excipient” refers to an excipient whose primary function is to modify the duration or place of release of the active substance from a dosage form as compared with a conventional immediate release dosage form.
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Tetrahydrofuran (THF) was used to dissolve the ionic liquid while the NaCl salt precipitated.
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The release of the (NM) contained in delayed-release (second) dosage form compartment initiated (meaning of “form compartment initiated” not clear) at least one hour after the first CNS active agent contained dosage form initiates release, with the initiation of the release generally occurring no more than six hours after initiation of release of CNS active agent from the first dosage form.
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Medications in this class differ in their dose, rate of absorption, duration.
The term “therapeutically effective amount” also refers to the amount of a compound that is sufficient to elicit the biological or medical response of a cell, tissue, system, animal, or human that is being sought by a researcher, veterinarian, medical doctor, or clinician.
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Other categories of CNS agents include benzodiazepines, barbiturates, opioids and other addictive drugs, analgesics, antipsychotics and antidepressants, muscle relaxants and nonbenzodiazepines, antispasmolytics, antihistamines and drugs for treatment of neurodegenerative diseases.
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Furthermore, because the disclosed ionic liquid compositions are liquid at a given temperature, they avoid problems associated with polymorphism.
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As used herein, something could be reduced but not prevented, but something that is reduced could also be prevented.
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