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Safety information about this potential drug interaction and important drug usage recommendations for emergency and non-emergency situations are being added to the drug labels for serotonergic psychiatric medications and linezolid.

From prior case studies, we estimated a culture-conversion rate of more than 90% with linezolid during the first 4 months of therapy, and on the basis of historical data, we assumed that less than 10% of patients would have spontaneous culture conversion without having received linezolid.

Complete blood counts should be monitored weekly in patients who receive linezolid, particularly in those who receive linezolid for longer than two weeks, those with pre-existing myelosuppression, those receiving concomitant drugs that produce bone marrow suppression, or those with a chronic infection who have received previous or concomitant antibacterial therapy.

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We have found linezolid to be very useful for the treatment of hVISA and VISA infections or infections with MRSA where vancomycin has failed.

Adverse drug reactions included rash and nausea and were the main reason for the discontinuation of therapy for 6 of the 9 nonevaluable patients, which were caused mostly by rifampin.

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Owing to preexisting neuropathy, 2 patients in the immediate-start group were withdrawn from the study before receiving any dose of linezolid and were excluded from the modified intention-to-treat analysis.

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The genotype of Staphylococcus aureus which is found to be the cause of the skin infection will be be compared to the genotype of Staphylococcus aureus present after treatment.

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The subsequent screening of seven university hospitals in Japan found no additional VISA strains but a rate of isolation of hVISA strains of between 9 and 20% of MRSA isolates by using a simplified “mini-PAP” procedure ().

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